Healthy subjects needed for kratom-drug interaction study. The study will investigate how a kratom product affects how the body processes another drug of interest.
This study will consist of four arms. During arm 1, you will be given kratom as a tea. During arm 2, you will be given the object drug. During arm 3, you will be given both kratom and the object drug. During arm 4, you will self-administer kratom at home for 4 days, and on day 5 you will be given both kratom and the object drug. During all arms, pupil diameter will be measured throughout the study day. During arms 2-4, blood samples and urine will also be collected. You will receive a screening medical exam and will undergo routine blood and urine laboratory tests.
You will receive
Up to $125 for completing Arm 1
Up to $300 for completing Arms 1 and 2
Up to $475 for completing Arms 1, 2, and 3
Up to $1,400 for completing all Arms of the study (1, 2, 3, and 4)
You may be eligible to take part in this study if you:
- Are from 21-45 years old and healthy
- Weigh between 130 and 250 lbs
- Have a body mass index between 19 and 30
- Are not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with your ability to eliminate the study drugs
- Are willing to abstain from consuming dietary/herbal supplements and fruit juices for several weeks
- Are willing to abstain from cannabis/marijuana, hemp, THC-, and CBD-containing products for several weeks
- Are willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm
- Are willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day
- Are willing to use an additional method of contraception that does not include oral contraceptive pills, patches, or other hormonal methods (such as abstinence, copper IUD, condom)
- Have consumed kratom previously and tolerated it well without unpleasant effects
- Are willing to abstain from taking kratom for at least two weeks prior to beginning the study and for the duration of the study
- Are geographically located within a 40-mile radius of Spokane and have the time to participate
You will not be eligible to take part in this study if you:
- Are under 21 or over 45 years old
- Weigh less than 130 lbs or more than 250 lbs
- Have a body mass index less than 19 or more than 30
- Are taking medications or dietary/herbal supplements that can interfere with your ability to eliminate the study drugs
- Have never taken kratom or have experienced unpleasant effects after taking kratom
- Have a chronic illness including but not limited to kidney disease, liver disease, diabetes mellitus, high blood pressure, coronary artery disease, chronic obstructive pulmonary disease, cancer, or HIV/AIDS
- Have a hematologic (blood) disorder
- Have a history of substance abuse, dependence, addiction or major psychiatric illness
- Have a need for chronic opioid pain medications
- Have used opioid pain medications within the last 3 weeks
- Have an upcoming need for opioid pain medications (e.g., planned dental or surgical procedure)
- Have a history of intolerance or allergy to kratom or opioids
- Have ever used amphetamines, benzodiazepines, cocaine, MDMA, opioids, PCP, or other drugs for recreational purposes
- Have used cannabis/marijuana, hemp, CBD-, and/or THC-containing products within the last month
- Are pregnant or nursing
- Are geographically located outside the 40-mile radius of Spokane and do not have the time to participate
- Cannot speak, read, and understand English
For more information about this study, please contact:
Deena Hadi, Program Manager
Phone: (509) 368-6692
Email: deena.hadi@wsu.edu
