The Department of Translational Medicine and Physiology welcomes Dr. Eric C. Holland, MD, PhD, Professor of Neurological Surgery at the University of Washington – School of Medicine, Fred Hutch Cancer Center, to WSU Spokane on Tuesday, March 17, 2026. He will be providing his seminar at 12:10 PM, “Big Data Visualization and Mouse Models of Cancer,” in SAC 147 and via Zoom.
Dr. Holland has used RNA seq of large numbers of clinically annotated tumors to generate dimension-reduced reference landscapes. These landscapes show clusters of similar tumors, subtypes, that have specific outcomes and biology based on their expression patterns. Mouse models of tumor subtypes genetically driven by the mutations found in human tumors recapitulate the expression patterns of the human diseases and can be aligned with the human reference landscapes.
Dr. Eric Holland is a world-renowned physician-scientist who combines compassionate patient care with exacting laboratory research to discover more effective treatments for brain tumors. As a neurosurgeon, Dr. Holland specializes in caring for patients with glioblastomas, aggressive cancers that are the most common malignant brain tumors in adults. Dr. Holland has many accomplishments, one is the development of mouse models of brain cancers, which researchers use to unravel tumor biology and test new therapies. His landmark work with mouse models also revealed that glioblastoma is not one but several diseases, a finding that is a first step toward tailoring treatment to individual tumors. Dr. Holland also studies the environment immediately surrounding tumor cells and how that neighborhood influences tumor formation and growth.
In person: SAC 147