Healthy subjects needed for a hemp-drug interaction study. The purpose of this research study is to determine if the botanical product hemp changes the behavior of pharmaceutical drugs in the body.
This study will consist of three study arms. During Arm 1, you will be given a single dose of clopidogrel, our object drug. During Arm 2, you will take one dose of hemp daily at home for five days. You will then return to the clinical study site, where you will be given the same dose of hemp and a dose of clopidogrel. During Arm 3, you will take a higher dose of hemp at home daily for five days. You will then return to the clinical study site, where you will be given the same dose of hemp and a single dose of clopidogrel. Blood will be drawn from an intravenous line during all arms. Urine samples will also be collected during those arms. The inpatient days for Arm 1 will be followed by an outpatient visit the following morning, when blood will be drawn, and you will return your urine jug(s). Arm 1 will be followed by one outpatient visit the next morning. Arms 2 and 3 will be followed by one outpatient visit each of the following three mornings. You will receive a screening medical exam and will undergo routine blood and urine laboratory tests, as well as a urine toxicology screen for common drugs of abuse prior to participating in the study.
You will receive
- up to $1,100 for completing the entire study
You may be eligible to take part in this study if you:
- are at least 21 years old and less than 65 years old and healthy;
- are not taking any medications (including prescribed clopidogrel), dietary/herbal supplements, or fruit juices that can interfere with your ability to eliminate the study drugs;
- are willing to abstain from cannabis/marijuana, hemp, THC, and CBD products for several weeks;
- are willing to abstain from consuming caffeine-containing products and beverages the evening before and the morning of each study day;
- are willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day;
- are willing to use an additional method of non-hormonal contraception (such as abstinence, copper IUD, condom);
- have consumed hemp or cannabis (in any form) previously and tolerated it well without unpleasant effects and are willing to abstain from taking it for at least two weeks prior to and for the duration of the study; and
- have the time to participate.
You will not be eligible to take part in this study if you:
- have a chronic illness or major psychiatric illness;
- have a hematologic (blood) disorder;
- have a history of any substance abuse, addiction, or dependence;
- are pregnant or breastfeeding;
- have a history of intolerance or allergy to hemp or clopidogrel;
- currently use or have recently used drugs or other illicit substances for recreational purposes;
- have used cannabis/marijuana, hemp, CBD-and/or THC-containing products within the past month and/or
- are taking concomitant medications, both prescription (including prescribed clopidogrel) and non-prescription (including dietary supplements/herbal products) known to alter the pharmacokinetics of clopidogrel; and
- are unable to speak, read, and understand English.
For more information about this study, please contact:
Deena Hadi, Program Manager
Phone: (509) 368-6692
Email: deena.hadi@wsu.edu
